Skype and other programs like it would be great for the classroom. When I was in college, I had a class where we had to help students in Hong Kong with their English. We worked via e-mail and instant messaging. However, if we had Skype, we could have worked on their English through practicing speaking and listening instead of just reading and writing.
I looked through the list of 50 Awesome Ways to Use Skype in the Classroom, and here are some of my favorites:
* Chat with an author, historian, artist, etc.- just like in Thing #1- sometimes, you just have to ASK! I'm sure there are a lot of people out there who wouldn't be able to get on a plane and talk to your class in person but would be willing to get on the computer to talk with students about whatever you ask them to talk about. You never know unless you ask.
* After-school help- If students are working on homework and message you on Skype to chat, you have the ability to tutor after school over the computer instead of in person.
* Skyping with other classes- This would have been beneficial for my college course. You can connect with other classes in the district, city, country, or even in foreign countries. Sometimes wikis and blogs just aren't enough, and if you're working on a collaborative project, students may get more out of talking and seeing.
* Inclusion- If a student has a circumstance that leaves them out of the regular classroom, it would be really cool to be able to include them in the every day classroom experience, especially when there's a project involved. I know my students can't stand when a group member is out of school while they're working on a project, so this is a good option for situations like these.